Nano-structured Biodegradable Ceramics for the Prevention and Treatment of Bone Cancer
نویسندگان
چکیده
In the present study, functionalized bioresorbable nanomaterials (less than 50 nm in size) were formulated to specifically attach to cancerous (not healthy) bone to form an implant used to treat bone cancer. After attachment, sustained release of anti-cancer agents occurred at targeted sites. Specifically, inorganic biodegradable nanomaterials (including ceramics like hydroxyapatite or HA) were functionalized with anti-cancer drugs (such as doxorubicin using covalent chemical attachment). The outer coating of the embedded nanoparticle systems will also be created to have different biodegradation rates for the controlled release of anticancer agents to the target site. In this study, we provide evidence of synthesizing highly degradable nano-amorphous calcium phosphate particles and slowly degradable nano-crystalline HA particles as drug delivery carriers to treat bone cancer.
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